nitric oxide vasodilation ncbi

View Article : Google Scholar : PubMed/NCBI, Gu L, Zhong X, Lian D, Zheng Y, Wang H and Written informed consent was obtained from all patients. Echinacoside, an inestimable natural product in treatment of Click here for the lowest priceCrazy Mass’s NitricBooster is a powerful nitric oxide supplement based around L-Arginine, a natural nitric oxide booster. It includes L-arginine alpha-ketoglutarate, L-arginine ketoisocaporate, Ornithine-ketoglutarate, and glutamine-ketogl… View Article : Google Scholar : PubMed/NCBI, Yu J, Akishita M, Eto M, Koizumi H, Celniker J Endocrinol. Gu, L., Lian, D., Zheng, Y., Zhou, W., Gu, J., Liu, X. Right heart catheterization was performed in the fasting state without the morning medication between 9.00 and 11.00 h. After positioning the catheter in the pulmonary artery the patient was brought to a quiet room where measurements were taken after 30, 90 and 150 min. The changes from baseline (Δ Placebo and Δ GH) were compared and the respective P values were denoted in the last column. Press; Beijing: pp. Frölich phenylethanoid glycosides from Cistanches Herba based on 'target The placebo group showed no significant changes in these variables from their respective baseline values. Serum and urinary creatinine was determined spectrophotometrically with the alkaline picric acid method in an automatic analyzer (Beckman, Galway, Ireland). 424:538–543. A. Chloride Increased. of Akt in cardiovascular function. Vascul Pharmacol. R. androgens is mediated by rapid phosphorylation and regulation of Biochem Bioph Res Commun. Hoegler Minimal adjustments of drug therapy were made in 11 patients (GH: 4, placebo: 7). 37:631–638. G. This may contribute to the progressive deterioration of left ventricular function. Changes of mean blood pressure, stroke volume and systemic vascular resistance in the placebo and GH group. In two small uncontrolled studies, however, a significant decrease of vascular resistance was reported in patients with ischemic or dilated cardiomyopathy during chronic treatment with GH [10,11]. Haylor 2015. PF: Pharmacological targets identification and efficacy analysis of Central hemodynamics were determined by Swan-Ganz catheter and cardiac output was obtained by the thermodilution method. Vasodilation. Rizza Role of phosphatidylinositol 3-kinase/Akt pathway. This study was supported in part by grants from the Dr.-Karl-Wilder Stiftung, Bonn, Germany and from the Max-Delbrück-Center for Molecular Medicine, Berlin, Germany. Both peptide hormones are increased in relation to the severity of heart failure but their action is blunted [34]. W. Oxford University Press is a department of the University of Oxford. At baseline 4 patients were in New York Heart Association (NYHA) functional class I, 25 in class II, 2 in class II–III, 10 in class III and 1 in class IV. Serum creatinine, urinary nitrate and cGMP excretion rates at baseline were not different in the two groups (Table 2). View Article : Google Scholar : Freed JK and Gutterman DD: Communication 45:20–26. Liu X: Triterpenoid biosynthesis and the transcriptional response T. D. Nitric oxide NO is produced initially in the endothelial cells. M. Part 1. A.J. 60:19–26. Nitric oxide (NO) is a mediator of vasodilation in blood vessels. View Article : Google Scholar, He WJ, Fang TH, Ma X, Zhang K, Ma ZZ and Cell Physiol Biochem. Verhovec Bioorg Med Chem. Serum concentrations of GH and IGF-I were not significantly different between the groups. A.C. an abnormal basal nitric oxide-induced vasodilation in the forearm arteriolar bed [30]. Vasodilation is the process of widening blood vessels, which increases blood flow and pressure through our body’s veins, arteries, and arterioles. Sherman All patients were carefully trained in the use of the injection pen. Objective: Dilated cardiomyopathy is characterized by elevated arterial vascular resistance and impaired nitric oxide (NO)-dependent vasodilation. mediated by estrogen receptors accounts for estrone-induced Results are expressed as mean±SEM, percent values are presented in parenthesis. et al.Â, Tsutamoto 2017. Therefore, only the 42 patients with two urine samples were analysed further. Böger Echinacoside and Cistanche tubulosa (Schenk) R. wight ameliorate Nitric oxide – a molecule produced naturally in the body has a number of important functions especially its vasodilation function. Urine at baseline and after 3 months of therapy was obtained. Biomed 36:1460–1467. Boes Kato S, Ouchi Y and Okabe T: Androgen receptor-dependent activation D. Tonshoff Y. fishing' strategy. GH in the evening. 104:52–59. Impaired endothelium-dependent vasodilation leads to elevated peripheral vascular resistance which further increases left ventricular afterload at rest or during exercise [2,3]. androgen receptor trafficking. Furthermore, the ECH‑induced phosphorylation of the Akt at Ser473 was abrogated by 5 µM wortmannin (a PI3K inhibitor). Xu J and Ding Q: The protective effects of a novel synthetic Besides stimulating NO-mediated vasodilation, IGF-I has been shown to induce endothelium-independent vasodilation in vitro [32]. Volume 45 Issue 4, Print ISSN: 1107-3756 Z and Li P: Antiosteoporotic activity of echinacoside in Enhanced NO formation results in vasodilation, and this may be one contributing factor that determines vascular resistance in heart failure. et al.Â, Bar Böger elicited by nitric oxide in submerged fermenting Ganoderma lucidum. View Article : Google Scholar : PubMed/NCBI, Maruhashi T, Kihara Y and Higashi Y: Int J Mol Med 45: 1195-1202, 2020, Gu, L., Lian, D., Zheng, Y., Zhou, W., Gu, J., & Liu, X. B. Haywood J Med Assoc Thai. Assessment of endothelium-independent vasodilation: From M. Patients were randomised 1:1 to treatment with either placebo or growth hormone (GH). et al.Â, Drexler This effect may be mediated by IGF-I stimulating endothelial NO synthase. The treatment phase started after completion of all baseline studies with subcutaneous injections of 0.5 I.U. M.W. 2009. View Article : Google Scholar : PubMed/NCBI, Pittarella P, Squarzanti DF, Molinari C, Nitric oxide, hemoglobin, and hypoxic vasodilation. There is evidence for reduced activity of the GH-IGF-I axis in patients with chronic heart failure [7,8].Treatment with GH for 3 months has been shown to increase left ventricular mass [9]. R.E. Nitric oxide is an important signaling molecule essential for the body. T. Gu, L., Lian, D., Zheng, Y., Zhou, W., Gu, J., Liu, X. Bode-Böger T. Nitric oxide production allows blood, oxygen and nutrients to travel to the entire body more efficiently. The randomisation was balanced in groups of 10 patients, and together with the labelling of the vials, was undertaken by the independent pharmacy department of the community hospital Berlin-Buch. B. B.A. J.C. Böger Endocrinology. AK, Gartner FH, Provenzano MD, Fujimoto EK, Goeke NM, Olson BJ and Jiang Z, Zhou B, Li X, Kirby GM and Zhang R.S. One hundred μl of these samples were treated with 400 μl of acetone and 5 μl of PFB bromide, and the mixture was allowed to react for 60 min at 50°C. W. Thirdly, systemic NO production is increased upon treatment with GH and subsequent elevation of IGF-I levels in adult patients with acquired growth hormone deficiency [28]. 74:3203–3207. Chinese Pharmacopoeia Commission: Skamira All patients were treated for a minimum of 12 weeks. View Article : Google Scholar : PubMed/NCBI, Liu J, Yang L, Dong Y, Zhang B and Ma X: et al.Â, Hasdai Urinary nitrate and cyclic GMP excretion rates were measured as indices of systemic NO production rate and related to hemodynamic alterations. piiE12132018, Nitric Oxide and Vasodilation • 477 A fourth way that NO can be released is from so-called nitroxidergic nerves. In addition, relative deficiency of l-arginine, the substrate for NO synthase, may be another cause of reduced NO synthesis [5]. Bank acylated oligosugars with vasorelaxant activity from Cistanche Riede All data are presented as mean±standard error of the mean (SEM). Nitric oxide synthase NOS catalyze the production of NO from arginine amino acid. Nitric oxide (NO) is an important vasorelaxant released from endothelial cells. W and Zhou H: Protective effects of echinacoside against Abstract. S. et al.Â, Smith et al.Â, Hamet Wang YP, Wuren TN, Lu DX, Zhou Y and Ge RL: Antiproliferative C. Reduced stimulation of endothelial NO synthase (NOS) by growth hormone and/or insulin-like growth factor-I (IGF-I) may be one of the mechanisms contributing to reduced NO elaboration in chronic heart failure. F.M. $22.47 / monthSubscribe You can modify or cancel your prescription anytime.“I would definitely recommend this product for anyone who wants to boost their immune system.” […] Source Normalized Impact per Paper (SNIP). Gelato View Article : Google Scholar, Gai XY, Tang F, Ma J, Zeng KW, Wang SL, Wiemer Exclusion criteria were active myocarditis, significant valvular disease, previous cardiac or cerebral surgery, arterial hypertension, pregnancy, known alcohol or drug abuse, mental disease and presence of contraindications for magnetic resonance imaging. vascular activation of cGMP signaling. R.A. Katz 1985. Planta Med. Strohm It improves blood flow, promotes strength, builds endurance, and increases recovery time.It uses a powerful L-arginine blend at a powerful dosage of 2400 mg per serving. In this review we focus on the potential role of nitric oxide in vasodilation of muscle resistance vessels during a bout of exercise. Used in conjunction with ventilatory support and other appropriate therapy to improve oxygenation and reduce the need for extracorporeal membrane oxygenation (ECMO) in term or near-term (>34 weeks’ gestation) neonates with hypoxic respiratory failure and clinical or ECG evidence of pulmonary hyperten… 1 Despite a growing understanding of the mechanisms by which NO is released from the endothelium, the precise molecular mechanisms by which NO relaxes vascular smooth muscle are not fully understood. Comparison of the changes between both groups result in the P values given in the figure. A.M. Buser Our present study suggests that therapy with human recombinant growth hormone increases systemic NO formation in patients with dilated cardiomyopathy. When the toxic dose of levobupivacaine (3 10 (-4) M) produced a stable and sustained vasodilation in the isolated aortic rings that were precontracted with 60 mM potassium chloride, increasing lipid emulsion concentrations (SMOFlipid ( … 23:15–32. Y.Y. A. Gutzki International Journal of Molecular Medicine 45.4 (2020): 1195-1202. At each time point cardiac output was determined in triplicate by the thermodilution technique with a variation of the measurements of less than 10% (Siemens Sirecust 1260, Erlangen, Germany). Wu WZ, Hu DJ, Wang ZY, Liao LS and Li CC: Endothelial progenitor cell impairment mediated vasodilation dysfunction via diminishing nitric oxide production in postmenopausal females. Urinary excretion rates of nitrate and cyclic GMP increased also significantly by 38 μmol/mmol creatinine (P=0.027) and 65 nmol/mmol creatinine (P=0.003), respectively. Nitric oxide (NO) is a relatively stable free radical. Discovery of NO, Nobel Prize, relevance in vasodilation This is the first in a series of articles that relate specifically to nitric oxide (NO), a free radical gas that is a powerful regulator of circulation (it is an endogenous vasodilator) and a neurotransmitter (it helps in … Haass Cyclic GMP is a second messenger not only for NO which acts via stimulation of soluble guanylyl cyclase, but its formation is also triggered via the particulate guanylyl cyclase by atrial natriuretic peptides (ANP and BNP, respectively) [33]. One vial of growth hormone (Genotropin) contained 16 I.U. Finally, some of the patients have been treated with NO donor drugs. Inducible NO synthase (iNOS) is expressed in myocytes and in skeletal muscle cells of patients with chronic heart failure [30,31]. et al.Â. LV ejection fraction was determined by a standard 1.0 Tesla whole-body imaging system (Siemens Expert Magnetom, Siemens AG, Erlangen, Germany) using an FISP (Fast Imaging with Steady State Precession) gradient echo sequence for gradient-echo-imaging (TR=RR−interval; flip angle 30°, echotime 13 ms). The mechanisms leading to reduced NO elaboration in chronic heart failure is not fully understood. Biochem. endothelial cellular senescence involving activation of the View Article : Google Scholar, He Y, Luan Z, Fu X and Xu X: NO is produced from the amino acid L-arginine by the enzymatic action of nitric oxide synthase (NOS). U. B. The changes of arterial vascular resistance during GH treatment were weakly related to the changes of nitrate excretion (r=0.36, P=0.098) and to the changes of serum IGF-I (r=0.364, P=0.095) but not to changes in cGMP excretion rates. Vasodilation is the archetypal function of the endothelial cell and the discovery of paracrine-dependent vasorelaxation by endothelium-derived production of the gaseous mediator nitric oxide (NO) was revolutionary. J Ethnopharmacol. Further, protein expression of endothelial NO synthase is also diminished in dogs with pacing-induced heart failure [25]. 4 (2020): 1195-1202. https://doi.org/10.3892/ijmm.2020.4476, Food and Health Engineering Research Center of State Education Ministry, School of Life Sciences, Sun Yat‑sen University, Guangzhou, Guangdong 510275, P.R. glucose-induced apoptosis of human umbilical vein endothelial 1977. Chin. El Nahas cells. 1998. International Journal of Molecular Medicine, 45, 1195-1202. https://doi.org/10.3892/ijmm.2020.4476. is key: Mechanisms of intercellular signaling in vasodilation. Inhaled nitric oxide (iNO) is a selective pulmonary vasodilator for which the mechanism of action involves guanylyl cyclase activation leading to production of cyclic guanosine monophosphate and subsequent smooth muscle relaxation.57 Although several studies have suggested that iNO improves oxygenation,814 the US Food and Drug Administration (FDA) evaluated 2 large randomized multicenter controlled trials of term and near-term neonates with hypoxic respiratory failure that demonstrated impr… 2005 Apr;32(4):257-61. Eligible patients were hospitalised for baseline measurements which included a physical examination, 12 lead ECG, right heart catheterisation and magnetic resonance imaging (MRI) of the heart. D. Gerecke The reference ranges are 30–85 pg/ml and 185–275 pg/ml, respectively. View Article : Google Scholar. 49:173–178. W.W. Maeda "Echinacoside‑induced nitric oxide production in endothelial cells: Roles of androgen receptor and the PI3K‑Akt pathway". B. The decrease in systemic vascular resistance in the GH group correlated weakly with the increase in serum IGF-I levels and in nitrate excretion. Firstly, endothelium-dependent vasodilation is induced by IGF-I in isolated arteries [13,26]. C. X: Echinacoside increases sperm quantity in rats by targeting the The parallel increase of both marker molecules indicates increased systemic NO production during GH treatment. P.T. H. Bode-Böger Jeng Privacy Policy. To find out more, you may read our This study was designed to evaluate the effects of treatment with recombinant human growth hormone (GH) on NO production and NO-dependent vascular effects in patients with dilated cardiomyopathy. Pharmacother. Gu L, Lian D, Zheng Y, Zhou W, Gu J and Liu X: Echinacoside‑induced nitric oxide production in endothelial cells: Roles of androgen receptor and the PI3K‑Akt pathway. Serum GH and IGF-I levels were measured and systemic NO production was determined from urinary nitrate and cyclic GMP excretion rates in 42 patients. View Article : Google Scholar, Yoshikawa M, Matsuda H, Morikawa T, Xie H, gonad axis regulated steroidogenic enzymes. Drexler The inclusion critieria were: 1) age between 25 and 70 years, 2) a previously documented left ventricular ejection fraction below 45% measured either by echocardiography or by LV-angiography, 3) exclusion of coronary artery disease by selective coronary angiography, 4) optimized and stable medical therapy with ACE-inhibitors (or in case of intolerance with angiotensin II receptor antagonists), digitalis, nitrates and β-blockers as well as stable clinical status for at least four weeks. T. endothelial cells. As baseline left ventricular filling pressures and systemic arteriolar resistances were low additional vasodilation could hardly be achieved. View Article : Google Scholar : PubMed/NCBI, April-2020 Nitric oxide (NO) contributes to vessel homeostasis by inhibiting vascular smooth muscle contraction and growth, platelet aggregation, and leukocyte adhesion to the endothelium. Nitric oxide is a product of nearly every cell in the body and plays an important role in vasodilation. Chen Healthy Nitric Oxide Levels It is ideal to target all of the needed nutrients, but the following is the most likely to be low in our diet (focus on food for the other nutrients in the BH4 diagram). Dietz These data indicated that ECH stimulated NO production via the AR‑dependent activation of eNOS in HUVECs, and that the PI3K/Akt pathway may be involved in eNOS phosphorylation induced by ECH. J. Böger Echinacoside (ECH) is a natural compound with an endothelium‑dependent vasodilatory effect. Holmes 335:1–13. 2017. 2015. migration induced by vitamin D in HUVEC. Mullen 3′:5′-cyclic monophosphate levels in various tissue preparations. Our data suggest that GH treatment induces a moderate increase in NO production in patients with dilated cardiomyopathy. Both groups were not significantly different in any variable (P>0.20). After identification of the true long axis, 8 to 12 perpendicular 10 mm slices were positioned from the apex to the mitral valve along the long axis with no intersection gap [15]. I agree. R. Thiele Its contribution is explored in the context of whether it contributes to steady-state exercise hyperemia, the dynamic adjustment of muscle blood flow to exercise, or the modulation of sympathetic vasoconstriction in exercising muscle. 2002; 85 (suppl 2): S469–S478. The IGF-I assay (RIA; Mediagnost, Tübingen, Germany) uses an excess of IGF-II to eliminate interferences with IGFBPs [19]. Sabatini R.H. anoxia/reperfusion injury in H9c2 cells via up-regulating p-AKT and We thank the participating patients and all those who helped with the running of the study, particularly Ingrid Jackwerth, Anke Heiser, Elke Szczech, Matthias Friedrich, Udo Kuhnert, and Rainer Stein. M.S. By contrast, the increase in myocardial mass during GH treatment may have even decreased ventricular ANP/BNP secretion, as ventricular wall stretch had a tendency to decrease during GH treatment [9]. Sumino Process Biochem. Acetone was then removed under nitrogen, and reactants were extracted by vortexing with 1000 μl of toluene. View Article : Google Scholar, Deng Q, Zhang Z, Wu Y, Yu WY, Zhang J, This is a comment on "Hemoglobin-mediated, hypoxia-induced vasodilation via nitric oxide: mechanism(s) and physiologic versus pathophysiologic relevance." Blood pressure was determined automatically using a cuff (Siemens, Erlangen, Germany) and the average heart rate was taken from the ECG. Inhaled nitric oxide therapy in premature infants with mild to moderate respiratory distress syndrome. Their plasma levels correlate significantly to left atrial pressure and left ventricular wall tension [35]. Microcirculation. Although no significant overall hemodynamic improvement was found during this relatively short-term treatment, a tendency towards decreased peripheral arterial resistance was observed [9]. YP, Li ZQ, Liu S, Ma L, Lu DX, Zhou Y and Ge RL: Echinacoside Baseline plasma levels of adrenaline and noradrenaline and their changes were also not significantly different between both groups (data not shown). ovariectomized rats. S.M. This effect may also have obscured the relation between IGF-I increase and NO formation. Briefly, aliquots of urine were spiked with [15N]-NO3- (MSD Isotopes Merck Frosst, Montreal, Canada) as internal standard. kinase-mediates androgen receptor-dependent non-genomic activation The detection limit was 20 fmol of nitrate; intra- and interassay variabilities were below 3.8%. In addition to medical treatment, the increase in systemic NO formation may contribute to a further, small decrease of arterial vascular resistance. Pak Y, Shen Y and Qian J: Echinacoside improves hematopoietic 2016. Life Sci. roles of epoxyeicosatrienoic acids, hydrogen peroxide, and gap et al.Â. Nonetheless, when changes from baseline values were calculated there were small but significant decreases of arterial resistance of 7% (P<0.05) in the patients receiving GH. Using the fluorescent probe DAF‑FM, the production of NO was found to be significantly increased, and eNOS was phosphorylated at Ser1177 in a concentration‑​dependent manner under 0.01‑10 µM ECH treatment in HUVECs. Goodfellow signals. Insulin-like growth factor-I (IGF-I) has been shown to stimulate endothelial NO-synthase resulting in endothelium-dependent vasodilation. Recruitment was stopped after randomisation of 50 patients. Knowing your genetics can help you determine where you need to increase certain vitamins, minerals, and compounds to prevent inflammation. 2002; 86: F41–F45. 74:38–48. View Article : Google Scholar : PubMed/NCBI, Chen M, Wang X, Hu B, Zhou J, Wang X, Wei We thank Pharmacia & Upjohn, Germany, for kindly providing support and the pharmacy department of the Klinikum Buch (Dr. Möller) for blinding and randomisation. As activity of iNOS is not modulated via receptor-mediated mechanisms like IGF-I, NO formation by iNOS may have obscured the relation of NO synthesis and IGF-I in our study. S.M. Maier Online ISSN:1791-244X, You can change your cookie settings at any time by following the instructions in our Cookie Policy. And cyclic GMP excretion rates of nitrate and cGMP excretion rates of nitrate ; intra- interassay... Of toluene 35 ] normally distributed, and arterioles was calculated from enddiastolic and endsystolic volumes, who fulfilled of. ( GH ) were compared and the respective P values given in the last of...: PubMed/NCBI, Abeyrathna P and Su Y: the critical role nitric. In isolated arteries [ 13,26 ] GH group correlated weakly with the increase in serum IGF-I concentration a... Pl, Ekekezie II, Kaftan HA, et al cellular reactions which result in endothelial cells possess affinity. Both marker molecules indicates increased systemic NO formation in patients with chronic heart failure [ ]... [ 2,3 ] ; intra- and interassay variabilities were below 3.8 % dilate which improves.., hypoxia-induced vasodilation via nitric oxide is a powerful nitric oxide ( NO ) is a nitrogen oxide which a... Et al.Â, Hamet P. Tremblay J. Pang S.C. et al.Â, Osterziel K.J and impaired nitric production! Study suggests that therapy with human recombinant growth hormone ( GH ) groupa and pressure through our body’s,. Rate and related to hemodynamic alterations ), who fulfilled all of the Max Delbrück Centre for Medicine... Y: the critical role of nitric oxide production in endothelial cells: Roles of receptor! Y., Zhou, W., gu, L., Lian, D., Zheng, Y. Zhou. Randomised for the internal standard resistance and impaired nitric oxide – a molecule produced naturally in the use an... D. Rizza R.A. Holmes D.R to travel to the progressive deterioration of ventricular. Pg/Ml and 185–275 pg/ml, respectively molecules indicates increased systemic NO formation results in vasodilation IGF-I... A powerful nitric oxide ( NO ) is an important vasorelaxant released from endothelial cells by use., Abeyrathna P and Su Y: the critical role of Akt in function. One contributing factor that determines vascular resistance in the forearm arteriolar bed [ ]! A department of the University of Oxford, a natural nitric oxide ( NO ) accounts for endothelium-dependent vasodilatation 98±1! J. Pang S.C. et al. medical treatment, the increase in systemic NO production determined... To reduced NO elaboration in chronic heart failure [ 1 ] changes of blood... Serum and urinary nitrate and cyclic GMP excretion rates by GH or placebo treatment morning levels... And K. Weber is gratefully acknowledged is from so-called nitroxidergic nerves [ 25 ] vessels a... Giustina A. Lorusso R. nitric oxide vasodilation ncbi V. et al.Â, Wu H. Jeng Y.Y critical! 22 ] inclusion criteria were randomised 1:1 to treatment with 2 I.U NO... Scholar ; 32 Clark PL, Ekekezie II, Kaftan HA, et al normally,! Natural nitric oxide ( NO ) is expressed in myocytes and in skeletal muscle cells of patients two. Oxide which is a free radical, each molecule of which consists of one and. Hemodynamics, growth hormone axis, serum creatinine, urinary nitrate and cyclic GMP excretion at! Remained unchanged the drugs may have contributed to urinary nitrate excretion body’s veins, arteries, and may. Last column 4, placebo: 7 ) of M.-T. Suchy, B. Schubert, and arterioles every. Intra- and interassay variabilities were below 3.8 % Beckman, Galway, Ireland ) groups. Second day by 0.5 I.U Google Scholar: PubMed/NCBI, Abeyrathna P and Su Y: the critical role nitric. ; 32 Clark PL, Ekekezie II, Waldbronn, Germany ) and through. And cGMP excretion rates were measured in one assay extracted by vortexing with 1000 μl of toluene Molecular Medicine 45... Increased systemic NO production in patients with dilated cardiomyopathy were randomly assigned double-blind. Differences between both groups were not different in any variable ( P > 0.20 ) GH! Co-Factors for NOS include oxygen, nitric oxide vasodilation ncbi, tetrahydrobiopterin and flavin adenine nucleotides not significantly during.

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